Keep an eye on Carefully (1)oxcarbazepine will reduce the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead to some lower in fentanyl plasma concentrations, deficiency of efficacy or, maybe, advancement of the withdrawal syndrome in a very patient that has produced Bodily dependence to fentanyl.
enzalutamide will reduce the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Coadministration of fentanyl with CYP3A4 inducers could lead on to your reduce in fentanyl plasma concentrations, lack of efficacy or, perhaps, improvement of a withdrawal syndrome in a patient who has designed Bodily dependence to fentanyl.
Watch Intently (one)dabrafenib will decrease the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead on to the reduce in fentanyl plasma concentrations, deficiency of efficacy or, possibly, enhancement of the withdrawal syndrome in a very affected person who has designed Bodily dependence to fentanyl.
fentanyl will increase the level or effect of tazemetostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
If coadministration of CYP3A4 inhibitors with fentanyl is necessary, keep an eye on patients for respiratory depression and sedation at Regular intervals and consider fentanyl dose changes till stable drug effects are accomplished.
Therapy might enhance frequency of seizures in patients with seizure disorders As well as in other clinical options associated with seizures; monitor patients for worsened seizure control during therapy
The above information is provided for general informational and educational purposes only. Specific options might fluctuate and formulary information changes. Contact the applicable program company for by far the most recent information.
Check Intently (one)phenobarbital will minimize the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Intently. Coadministration of fentanyl with CYP3A4 inducers could lead on to the reduce in fentanyl plasma concentrations, insufficient efficacy or, perhaps, advancement of a withdrawal syndrome in a patient who has produced Actual physical dependence to fentanyl.
Reserve concomitant prescribing of these drugs in patients for fentanyl music whom other treatment options are inadequate. Limit dosages and durations to the minimum necessary. Observe intently for signs of respiratory depression and sedation.
Check Closely (one)bosentan will lessen the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead on into a lessen in fentanyl plasma concentrations, not enough efficacy or, maybe, progress of the withdrawal syndrome in a individual who's got made physical dependence to fentanyl.
fentanyl will raise the level or effect of flibanserin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of. Increased flibanserin adverse effects may perhaps take place if coadministered with many weak CYP3A4 inhibitors.
Watch Closely (one)dexamethasone will minimize the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Coadministration of fentanyl with CYP3A4 inducers could lead to the lessen in fentanyl plasma concentrations, deficiency of efficacy or, perhaps, progress of a withdrawal syndrome inside a affected person that has created physical dependence to fentanyl.
turmeric will boost the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
fentanyl and fentanyl intranasal each boost sedation. Stay clear of or Use Alternate Drug. Restrict use to patients for whom option treatment options are inadequate